凯文·谢伊
Professor of 化学istry; Chair of the 化学istry Department
传记
凯文·谢伊 focuses on organic chemistry. His lab uses organic synthesis to investigate new methods for carbon-carbon bond formation and to develop syntheses of biologically active molecules. Completed research has focused on the application of tandem Nicholas and Pauson-Khand reactions for the synthesis of tricyclic heterocycles.
Ongoing research involves expanding the use of cobalt-alkyne complexes in organic synthesis. One goal is to develop a tandem Diels-Alder/Pauson-Khand protocol for the production of tetracyclic compounds using a diene containing a cobalt-complexed alkyne. Another project involves production of cyclic alkynes via the Nicholas reaction for use in click chemistry applications.
One newer project involves a collaboration with Steve Williams's molecular biology laboratory at Smith. The goal is to identify new molecules to combat lymphatic filariasis, and we have already seen some success with natural and synthetic neurolenin derivatives.
He is also interested in the scholarship of teaching and learning, especially related to teaching organic chemistry in the lecture and the laboratory. He is a practitioner of active learning and readily incorporates technology. He also pioneers innovations like course-based research in organic teaching labs.
选定的出版物
谢伊,K. M.; Williams, S. A. “Neglected Nematodes: The Neurolenin Story” 研究功能 2021 DOI 10.26904/RF-134-146149
Nickerson L. A.; 谢伊,K. M. “First-Semester Organic 化学istry during COVID-19: Prioritizing Group Work, 灵活性, 与学生参与,” J. 化学. 建造. 2020, 97, 3201-3205.
巴内特,K. L.; 谢伊,K. M.; *McGeough, C.; *Trotta, K.; Williams, S.; Ly, M.; Aloisio, K. “Semester-Long Course-Based 研究 Project in Second-Semester Organic 化学istry: Synthesizing Potential Lead Compounds for the Treatment of a Neglected Tropical Disease,” J. 化学. 建造. 2020, 97, 1008-1016.
谢伊,K. M. “Student Use of Classroom Response Systems to Promote Active Learning,” In Active Learning in Organic 化学istry: Implementation and Analysis; Houseknecht, J. B.列昂捷夫，A.马洛尼，V. M.，焊工，C. O., Eds.; ACS Publications, 2019, Chp 6, 87-97.
Gorin D. J.; Jamieson, E. R.; Queeney, K. T.; 谢伊,K. M.; Spray, C. G. R “The “pHunger Games”: Manuscript Review to Assess Graduating 化学istry Majors,” J. 化学. 建造. 2016, 93, 2058-2062.
Chowdhury L.; Croft, C. J.; Goel, S.; Zaman, N.; Tai, A. C.-S.; Walch, E. M.; Smith, K.; Page, A.; 谢伊,K. M.; Hall, C. D.; Jishkariani,D.; Pillai, G. G.; Hall, A. C. "Differential Potency of 2,6-Dimethylcyclohexanol Isomers for Positive Modulation of GABAA 受体电流。” J. 制药. 经验值. Therap. 2016, 357, 570-579.
谢伊,K. M. "Beyond Clickers, Next Generation Classroom Response Systems for Organic 化学istry," J. 化学. 建造. 2016, 93, 971-974.
谢伊,K. M.; Gorin D. J.; Buck, M. E. "Literature-Based Problems for Introductory Organic 化学istry Quizzes and Exams," J. 化学. 建造. 2016, 93, 886-890.
Rudnitsky,.埃利斯，G.迪巴托洛，P. M.谢伊，K., "Developing a 教师 Learning 社区 Grounded in the Science of How People Learn: A Year-Long, 教师-Led Teaching and Learning Seminar," 提高学院水平, 2013, 127-144.
Thomas R. M.谢伊，K. M., "Synthesis of Di and Trisubstituted Azulenes Using a Danheiser Annulation as the Key Step: An Advanced Organic Laboratory 经验值eriment," Journal of 化学ical 教育, 2013, 90, 110114.
奥尔森J. A.谢伊，K. M., "Additions and Corrections to Critical Perspective: Named Reactions Discovered and Developed by Women," Accounts of 化学ical 研究, 2012, 45, 482-483.
奥尔森J. A.谢伊，K. M., "Critical Perspective: Named Reactions Discovered and Developed by Women," Accounts of 化学ical 研究, 2011, 44, 311-321.
谢伊,K. M., "The Diels-Alder Reaction," Name Reactions for Carbocyclic Ring Formations; Li, J. J., Ed.; Wiley & 儿子公司.: Hoboken, NJ, 2010; 275-308.
秘密地,K. D.昆塔尔，M. M.谢伊，K. M., "The Scope and Limitations of Intramolecular Nicholas and Pauson-Khand Reactions for the Synthesis of Tricyclic Oxygen- and Nitrogen-Containing Heterocycles," The Journal of Organic 化学istry, 2009, 74, 3680-3688.
谢伊,K. M.，“尼古拉斯反应”， Name Reactions for Homologations-1; Li, J. J., Ed.; Wiley & 儿子公司.: Hoboken, NJ, 2009; 284-298.
谢伊,K. M.《澳门葡京博彩软件》， Name Reactions for Homologations-2; Li, J. J., Ed.; Wiley & 儿子公司.: Hoboken, NJ, 2009; 452-463.
谢伊,K. M., "Martin's Sulfurane Dehydrating Reagent," Name Reactions for Functional Group Transformations; Li, J. J.科里，E. J., Eds.; John Wiley & 儿子公司.: Hoboken, NJ, 2007; 248-264.
谢伊,K. M., "Furans and benzo[b]furans," Palladium in Heterocyclic 化学istry: A Guide for the Synthetic 化学ist; 2nd edition, Li, J. J.格里布，G. W., Eds.; Elsevier: Boston, MA, 2007; 303-344.
谢伊,K. M.，更近，K. D.昆塔尔，M. M., "Nicholas Reactions with Carboxylic Acids for the Synthesis of Macrocyclic Diolides," The Journal of Organic 化学istry, 2005, 70, 9088-9091.
公担,M. M.，更近，K. D.谢伊，K. M., "Tandem Intramolecular Nicholas and Pauson-Khand Reactions for the Synthesis of Tricyclic Oxygen-Containing Heterocycles," 有机的信, 2004, 6, 4949-4952.
克龙比式,. L.凯恩，J. L., Jr.谢伊，K. M.Danheiser, R. L., "Ring 经验值ansion-Annulation Strategy for the Synthesis of Substituted Azulenes and Oligoazulenes. 2. Synthesis of Azulenyl Halides, 磺酸盐, and Azulenylmetal Compounds and Their Application in Transition-Metal-Mediated Coupling Reactions," The Journal of Organic 化学istry, 2004, 69, 8652-8667.
谢伊,K. M., "FeistBénary Furan Synthesis," Name Reactions in Heterocyclic 化学istry; Li, J. J., Ed.; John Wiley & Sons: Hoboken, NJ, 2004; 160-167.
谢伊,K. M. "PaalKnorr Furan Synthesis," Name Reactions in Heterocyclic 化学istry; Li, J. J., Ed.; John Wiley & Sons: Hoboken, NJ, 2004; 168-182.
凯恩,J. L., Jr.谢伊，K. M.克龙比，A.Danheiser, R. L., "A Ring 经验值ansion-Annulation Strategy for the Synthesis of Substituted Azulenes. Preparation and Suzuki Coupling Reactions of 1-Azulenyl Triflates," 有机的信, 2001, 3, 1081-1084.
谢伊,K. M.李，K. L.Danheiser, R. L., "Synthesis and Properties of 9-Alkyl- and 9-Arylcyclopenta[a]phenalenes," 有机的信, 2000, 2, 2353-2356.